Prof. Ryusuke Ae
Division of Public Health, Center for Community Medicine,
Jichi Medical University
Data analysis project in medical and engineering collaboration by big data in Kawasaki Disease
Half a century has passed since Dr. Tomisaku Kawasaki first reported patients with Kawasaki disease (KD) from Japan. Recently, KD has been reported worldwide and in children of all races and ethnicities. Some patients with KD develop coronary artery abnormalities, which is a global issue as it is the current leading cause of acquired heart disease in children. Nevertheless, the cause of KD remains unidentified.
In Japan, a nationwide KD survey has been conducted since 1970, aiming to provide evidence that may suggest clues that could help identify KD pathogenesis. To date, the database contains approximately 420 thousand patients with KD; this is one of the largest patient registration databases worldwide. We have established an interdisciplinary research team to analyze KD database as an example of medical–engineering collaboration with effective programming techniques for big data analysis. In this lecture, we talk about the collaboration work with some informative results from big data analysis.
Dr. Ryusuke Ae is currently a professor at Jichi Medical University. After graduating from Jichi Medical University in 2003, he was engaged in primary healthcare in rural communities in Hyogo prefecture as a physician for ten years. His medical specialty is general internal medicine (Fellow of the Japanese Society of Internal Medicine) and geriatrics (Board certified Geriatrician: the Japan Geriatric Society). After his clinical experience, he has been an epidemiologist at Jichi Medical University since 2013. While a Regular Research Fellow at the Centers for Disease Control and Prevention (CDC) during 2018–2019, he received several awards for skilled analysis of complex Kawasaki disease data and a relevant publication. He is interested in practical medical–engineering collaboration to find epidemiological evidence that may result in identifying the etiology of Kawasaki disease.
Prof. Satoshi Yokojima
School of Pharmacy,
Tokyo University of Pharmacy and Life Sciences
Theoretical investigation of reversible fluorescent photoswitching molecules upon irradiation with visible light
One of the problems of conventional photoswitches is in the use of UV light as the trigger of the switch in at least one direction. Since UV light induces harmful reactions and since UV light is absorbed at the surface in most materials, it is preferable to use visible or IR light for controlling a photoswitch. Thus, the development of photoswitches controlled by visible or IR light is recently quite active. We theoretically investigated the mechanism of a switch of one of such photoswitching organic molecules, a fluorescent dye attached diarylethene. We show the photoswitching reaction upon irradiation with green light occur due to multiplicity conversion based on intramolecular energy transfer from the excited singlet state of the fluorescent dye to the triplet state of diarylethene.
Satoshi Yokojima studied field theory in physics at Keio Univ.. He received PhD in 1995 supervised by Prof. R. Fukuda. He then worked on optical response with Prof. S. Mukamel at Univ. of Rochester. He moved to Univ. of Hong Kong and developed a linear scaling method with Prof. G.H. Chen. After working with Prof. Y.J. Yan on dissipative systems, he studied a charge transfer in DNA with Dr. A. Okada at Univ. of Tsukuba. He joined Dr. S. Nakamura’s group at Mitsubishi Chemical and worked on photochromic systems. He moved to Tokyo Univ. of Pharm. and Life Sci. in 2011 and promoted to Professor in 2016.
Dr. Hiroshi Yokota
Graduate School of Human and Environmental Studies,
Simulation study on “torsion” and local structure of chromosome: Loop structure via one side loop extrusion with twist deformation
In eucaryotic cell, during cell division, genome DNA condenses into the rod-like shape so called chromosome. The rod-like shape comes from consecutive loop structures constructed by condensin (protein complex).
Experiments show that condensin binds with DNA through the two binding sites, and then, pushes (extrudes) either of the binding sites. Such a one side loop extrusion creates DNA loops. Molecular dynamics simulations, however, show the fails of the chromosome condensation by only a one side loop extrusion.
In this talk, we would like to talk about loop structures by one side loop extrusion with twist deformation (a kind of “torsion” deformation) based on coarse-grained molecular dynamics simulation. Moreover, each structure is compared with some experiments in vivo and in vitro.
Hiroshi Yokota is currently a postdoctoral researcher in Graduate School of Human and Environmental Studies, Kyoto University. He received his Dr. in Department of physics, Tohoku University in 2019. After he received his Dr., he had been working as a postdoctoral researcher at RIKEN 2019-2023. He has theoretically studied chromosome condensation and polymer crystallization based on soft matter physics.